THE FIRST LONG-TERM STUDY COMPARING TYPE 2 DIABETES MEDICATIONS LAUNCHES NATIONWIDE. SEEKS VOLUNTEERS.

The GRADE Study is Sponsored by the The National Institute of Diabetes and Digestive and Kidney Diseases, NIH

/ PRNewswire / — The first comprehensive long-term study comparing different medications for type 2 diabetes is launching nationwide. The GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness) Study will compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes.
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The GRADE Study is sponsored by The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. It being coordinated by the Biostatistics Center, a research facility of The George Washington University.

“What differentiates GRADE from previous studies is that it will perform a head-to-head comprehensive comparison of the most commonly used drugs over a long period of time. This type of comparison has never been done before,” said David M. Nathan, MD, Director of the Massachusetts General Hospital Diabetes Unit, Professor of Medicine, Harvard Medical School and Chairman of the GRADE Study.

The GRADE Study will compare the effects of four glucose-lowering medications: the sulfonylurea, glimepiride; DPP-4 inhibitor, sitagliptin; GLP-1 agonist, liraglutide; and basal insulin, glargine; when each is added to metformin.

5,000 patients will be enrolled in up to 50 academic and VA medical centers nationwide. Patients will be followed for up to seven years. Participants will have their diabetes medications managed free of charge throughout the study, including at least four medical visits per year.

Anyone interested in learning more about the GRADE Study, can visit the study website at www.gradestudy.org to find the contact information for the medical center in their area.

The GRADE Study (ClinicalTrials.gov number: NCT01794143) is supported under NIH grant U01DK098246.

About Type 2 Diabetes
Type 2 diabetes is an epidemic that threatens to become the century’s major public health problem and poses enormous human and economic challenges worldwide. Nearly 26 million Americans are affected by diabetes, and 79 million have pre-diabetes.

About the Biostatistics Center
The Biostatistics Center is a research facility of The George Washington University under the Office of the Vice President for Research. The Center serves as the coordinating center for large-scale multi-center clinical trials and epidemiologic studies. Established in 1972, the Center participates in major medical research programs of national and international scope, frequently leading to major medical advances.

Participating Physicians

Deborah Wexler, MD
Massachusetts General Hospital
Boston, MA

William Tamborlane, MD
Yale University
New Haven. CT

Anne Camp, MD
Fair Haven Community Health Center
New Haven, CT

Xavier Pi-Sunyer, MD
St. Luke's-Roosevelt Hospital Center
New York, NY

Robin Goland, MD
Columbia University
Naomi Berrie Diabetes Center
New York, NY

Jill Crandall, MD
Albert Einstein College of Medicine
Bronx, NY

Mary Ann Banerji, MD FACP
SUNY Downstate Medical Center / Kings County Hospital Center
Brooklyn, NY

Daniel Lorber, MD
New York Hospital Queens
Flushing, NY

Vanita Aroda, MD
MedStar Health Research Institute
Hyattsville, MD

Kristi Silver, MD
University of Maryland-Baltimore,
Baltimore VAMC
Baltimore, MD

Robert Cohen, MD
University of Cincinnati
Cincinnati VA Medical Center
Cincinnati, OH

Kieren Mather, MD
Indiana University
Indianapolis, IN

William Herman, MD MPH
University of Michigan
Ann Arbor, MI

William Sivitz, MD
University of Iowa
Iowa City, IA

Richard Bergenstal, MD
Park Nicollet International Diabetes Center
St. Louis Park, MN

Elizabeth Seaquist, MD
University of Minnesota
Minneapolis, MN

Ananda Basu, MD FRCP
Mayo Clinic
Rochester, MN

Janet McGill, MD MA FACE
Washington University in St. Louis
St. Louis, MO

Cyrus Desouza MBBS
University of Nebraska Medical Center
Omaha VA Medical Center
Omaha, NE

Vivian Fonseca, MD
Tulane University
New Orleans, LA

Helen Petrovitch, MD
Pacific Health Research & Education Institute / VA Pacific Islands Healthcare System
Honolulu, HI

Andrew Ahmann, MD
Oregon Health and Science University
Portland, OR

Dace Trence, MD
University of Washington
Seattle, WA

Kristina Utzschneider, MD
Seattle Institute of Biomedical & Clinical Research (VA Puget Sound)
Seattle, WA
Sue Kirkman, MD
UNC Diabetes Care Center
Durham, NC
Greensboro, NC

Jennifer Green, MD
Duke University Medical Center
Durham, NC

Lawrence Phillips, MD
Atlanta VA Medical Center
Decatur, GA

Joshua Barzilay, MD
Kaiser Permanente of Georgia (Atlanta)
Kaiser Permanente of Georgia (Duluth)
Atlanta, GA

Hermes Florez, MD
Miami VA Healthcare System
Miami, FL

Jennifer Marks, MD
University of Miami
Miami, FL

Timothy Garvey, MD
University of Alabama at Birmingham
Birmingham, AL

Sam Dagogo-Jack, MD
University of Tennessee Health Science Center
Memphis, TN

Faramarz Ismail-Beigi, MD
Cleveland VA Medical Center
Cleveland, OH

Corinna Falck-Ytter, MD
MetroHealth Medical Center
Cleveland, OH

William Cefalu, MD
Pennington Biomedical Research Center at LSU
Baton Rouge, LA

Priscilla Hollander, MD PhD
Baylor Endocrine Center
Dallas, TX

Philip Raskin, MD
University of Texas-Southwestern Medical Center
Dallas, TX

Ashok Balasubramanyam, MD
Baylor College of Medicine
Houston, TX

Ralph DeFronzo, MD
University of Texas Health Science Center
San Antonio, TX

Neda Rasouli, MD
University of Colorado-Denver
Aurora, CO
Denver VA Medical Center
Denver, CO

Jonathan Krakoff, MD
Southwestern American Indian Center/NIH
Phoenix, AZ

David Schade, MD
University of New Mexico
Albuquerque, NM

Robert Henry, MD
VA San Diego Healthcare System / UC San Diego
San Diego, CA